Depending on the design, games with females as main leads, are being catered towards male players. Putting a male as main lead, despite the design is aimed at general audience.
The rest is decided by amount of explosions, crappy plot, bitches, tits, pecks (mainly on MC) and handsomness and badassery of the main lead.
Not many girls play games where the main character is a sexy girl in some slutty skimpy outfit. Guys play those games to ogle as mostly they lack story, sense or anything of note (other than tits, possible awkward poses in combat or other sexualized themes)
So as said already, despite design, male protagonists games are aimed at general audience, which means anyone can enjoy it.