It's set in modern day USA and the target audience is the same.
Betrayal can be incorporated, betraying humanity. Starting wars and conflicts, purposefully creating 3 nearly identical religions to that end, promising afterlife when there is no intention of granting it, and so on.
I'm going to assume you mean mainstream Americans since true universality is still nigh impossible (there's always a few fringe group with totally different morals).
So, the vast majority of Americans are individualistic moderates, or at least want to be. They value life, liberty, and the pursuit of happiness. Consequently, anything that goes against those values is considered "evil" by most Americans.
Murder is considered evil, unless the victim is also a perpetrator of evil, in which case it's considered anything from necessary evil to "Ding Dong The Witch Is Dead!". Murdering those who have no way of resisting, such as children or disabled, is considered even worse evil.
Abortion is generally considered evil unless done to prevent greater loss of life (in other words, the mother isn't expected to survive pregnancy). Casually aborting for reasons summarized as "I feel like it" is likely to get you labeled as somewhat evil. Forcing abortion on other people is held on the same level as murder.
Letting someone die when you could have saved them is considered evil. The degree of this depends on the amount of expected responsibility between the observer and the victim.
Classism, racism, and any type of system that limits the liberty of people because of factors beyond their control is considered evil.
Poverty is considered evil when inflicted upon other people. It is often considered evil to drive people out of business or force them out of work, unless said people are powerful or labeled evil themselves.
Exception: Acting against social or legal obligations is considered evil despite obligations placing a limit on liberty. A person is expected to make more effort towards taking care of family compared to that of a stranger. A fireman is expected to put out fires, a policeman is expected to stop a crime, a doctor is expected to do no harm. Going against these social/legal obligations is considered evil.
Actions which are perceived to make the majority unhappy are considered evil. This can range from putting certain careers out of the theoretical reach of the majority, to going against fan expectation in entertainment.
Intentionally making people sad is considered evil, unless it makes a greater number of people happy.
Teaching children values which differ from the observer's values is considered evil. (As compared to cultures which encourage multiple moral systems such as Hinduism, Mahayana Buddhism, or Anarchism.)
Foreign domination of the worldwide economy or culture is considered evil. American domination of the worldwide economy or culture is considered good.
Differences in foreign cultural values are considered quaint and to be tolerated, unless it is "important" or "personal", in which case it is considered good to force American values.
Note: These are all general statements based on my opinion formed from observations of American behavior and media and how they practice/display morality. They're not supposed to be empirical facts, nor are they universal even inside the USA.