Nodame Cantabile would probably get my first spot, if I included the second season in my thinking.
I kind of got sick of Chiaki's aerophobia being a major contention, seeing as you can take a boat for relatively the same costs these days - and his relative perfectness disoriented me as well. There were times when I wasn't sure if it was a romantic comedy or a niche slice-of-life, as no relationship was progressing, it was just various people drooling over Chiaki as he tried to ignore them and seek his dreams. Season two however, has been focusing more on the romantic aspect, and I've been enjoying it thoroughly.
Aishiteruze Baby would be my other contender, I enjoyed the warm tingly feeling the series left me with.