I know there are a bunch of animes that I saw that were sad but i don't know if I can remember them...
Honey and Clover I+II are really serious, has a lot of good characters, and a deep message. It has comedy but its not the sort of anime you would come away from laughing at all the good times...
Kare Kano: Comedy with some serious moments... probably 1/2 and 1/2 comedy drama ratio
Read or Die TVSorry, I guess I forgot a ton.
