Oregon Trail, maybe with a little more realism.
Back when I played Oregon Trail, I only found 2 parts to be fun. The hunting and the river rafting. I really didn't give a fuck if one or two people died of scurvy or dysentery.
If they re-did it with today's graphics, they'd have to do some serious work on the in-between. Like maybe put some Indian attacks in there, where you'd you'd have to circle the wagons and FPS some Indians with a musket or something.
Either that or turn it into a visual novel, to make it more personal. Have cut-scenes where "Mary" is coughing up blood...
"I'm so cold. *cough* Onii....chan."
<Increase rations> or <Decrease rations> ?
*Increase rations*
... <Your choice didn't matter. Mary died of tuberculosis>
FFFFFFFFFFFFUUUUUUU
UUUUUCCCCK....