Since noone else is commenting this series, and I figure you want some response at least, I'll utter a few lines even though I might not dwelve into things like if Chiko/Tome/Koito is hawt or not.
First off I'm not a huge Bones fan, even though I can recognize they have high production values in most areas. The main reason for this is their ability to tying a plot up. They usually have stunning animation, beautiful soundtrack, interesting characters, and a promising start. But the plot is almost always a bit too thrown up, with no real destination.
Some people argue that the journey is more important than the conclusion itself (the by far most common argument when I've pointed this out), and although I understand this viewpoint, most of the animes Bones make are very plot-driven, even if it ultimately is for the characters' development. They usually focus so much on the plot and give it so much attention that it cannot be ignored, and when the ending comes, many important plots (or so they seemed during most of the series) are very seldom tied up in a satisfactory manner. Which makes a person like me wonder how the plot progressed the way it did, and following this I question the characters because they reacted to the "nonsensical" plot devices and circumstances.
For instance RahXephon, Wolf's Rain, Eureka 7, Bounen no Xamdou, and Darker than Black all suffers from this to a smaller or bigger degree, but I've still liked all of them. I've particuarly liked the stunning animation and beautiful soundtrack and they have some really cool original ideas as well. I just think they could be even better in the plot deparment from beginning to end (like Stranger of the Sword, it was a movie and the plot was forced to be kept short, simple and concist, and I thought it turned out really well). If they could do that consistently I'd instantly be as a huge fan as most of today's community seem to be of Bones studio
After this general remark about the studio in itself, I think Nijuu Mensou no Musume is mildly entertaining, and the production values aren't as high as I've seen them do; felt more like a average work for them. Average animation, nice artwork, unmemorable music, decent characters, interesting premise but ultimately not truly interesting at all. I'd give it around 6/10, but I'm probably stricter with my rating than the average guy.
As I said mildly entertaining, certainly watchable, but does not posses anything extra that makes it worth recommending.