Tried a quick forum search for something like this. I'd think it'd have come up, but I either ended up with nothing relevant for narrow searches, or 30+ pages of seemingly irrelevant posts for broader searches.
Anyway, I know they're just games, but I was recently playing Kanon, and having rejected taiyaki for the fifth or so time I felt kinda bad. Previously I was just skipping most of the early dialog because I'd seen both shows, but actually reading it made me feel like a bit of an ass/jerk/"meany".
Having watched the anime, I also felt pretty low for leaving Makoto at the shopping center when I wasn't playing her route...
More Western-y, I also feel like a bit of an ass when I play ME 1/2 non-Paragon characters. x.x
So, I thought I'd create a thread and see what other people thought in general, especially since an anime themed forum would probably have a higher concentration of VN players.

Feel free to share your experiences or thoughts (behind spoiler tags as necessary), but try to keep flaming to a minimum. I realize the "it's just a game" option is there, but I'm -pretty- sure most people know that already, so I see no need to get too up in arms about it.
-edit- I guess I stressed the VN aspect a bit too much. I meant games in general. The VN bit is just a recent example for me.