Wow. Lots to process. Thanks for all the input. Allow me to throw two more desired elements into the pot:
-Moral Ambiguity; no clear delineation between antagonist and protagonist, a departure "good guys vs. bad guys, good guys win"-type plot construction.
-Visual Feast; dramatic, dynamic, creative, psychedelic or otherwise aesthetically eye-popping animation, with respect to both set/character design and cinematography/style.
That's in addition to:
-Tasteful/thought provoking use of "adult" themes (violence, death, sex, poverty, vice, war, etc.)
-Environmental take-away message(s)
A side note:
Have seen many works of Satoshi Kon. Some need re-watching to determine how well they fit this wishlist.
My ongoing 'Thanks' to the contributors to this thread. Looking forward to more.