Kemono no Souja Erin, nothing to add to Al_Sleepers recommendation regarding that one. Only one tip, skip episode 25.
Monster, it is on your To Watch-list, really intense series.
Shinsekai Yori, I wouldn't call it hard to follow, just something with shouldn't be watch together with other distractions.
Seirei no Moribito, one of the few strong contenders for a fantasy/medival setting.
Yomigaeru Sora: Rescue Wings
Uchouten Kazoku
Silent Möbius
Saiunkoku Monogatari, cast resembles a reverse harem, but definitly a nice watch
Real Drive, a little weak the show, but interesting setting and character designs
Nodame Cantabile, on your To-Watch list
The Daughter of Twenty Faces (Nijuu Mensou no Musume), a pretty underrated anime, give it a try, maybe it will surprise you
Natsume Yuuchinjou, pretty interesting world and characters, sadly no really strong overreaching story arc, but character progress, but really slow
Victorian Romance Emma, on your To-Watch list
Please give some feedback for these shows, if these are near your desired thematic or not so much.